Organic Chemistry MCAT Practice Exam 2025 – 400 Free Practice Questions to Pass the Exam

Iron (III) chloride (FeCl3) plays a crucial role in electrophilic aromatic substitution as a catalyst. In this process, the aromatic ring, which is rich in electrons, undergoes substitution with an electrophile. The electrophile is often generated in situ from a reactant through the action of the catalyst.

FeCl3 specifically facilitates the reaction by coordinating to the electrophile, increasing its electrophilicity, and creating a more reactive species that can effectively attack the electron-rich aromatic ring. By lowering the activation energy of the reaction, FeCl3 helps to accelerate the rate of substitution without being consumed in the process. After the reaction, it can release from the complex and be available to participate in additional reactions, thus confirming its role as a catalyst.

Understanding this catalyst function highlights the importance of transition metal halides in organic reactions, particularly in generating and stabilizing reactive intermediates that are essential for the success of electrophilic aromatic substitutions.